Quarterly report pursuant to Section 13 or 15(d)

Summary of Significant Accounting Policies - Schedule of Potentially Dilutive Shares (Details)

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Summary of Significant Accounting Policies - Schedule of Potentially Dilutive Shares (Details) - shares
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Stock options        
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]        
Anti-dilutive securities (in shares) 4,073,449 2,888,146 4,110,108 2,888,146
Warrants to purchase Series C-1 Preferred | Warrant liability        
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]        
Anti-dilutive securities (in shares) 14,033 14,033 14,033 14,033
Warrants to purchase common stock associated with Loan Agreement | Warrant liability        
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]        
Anti-dilutive securities (in shares) 122,435 122,435 122,435 122,435
Warrants to purchase common stock associated with June 2016 Public Offering | Warrant liability        
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]        
Anti-dilutive securities (in shares) 4,218,750 4,218,750 4,218,750 4,218,750
March 2018 Public Offering Series 1 [Member] | Warrant liability        
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]        
Anti-dilutive securities (in shares) 13,198,075 0 13,198,075 0
March 2018 Public Offering Series 2 [Member] | Warrant liability        
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]        
Anti-dilutive securities (in shares) 7,988,175 0 7,988,175 0