FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Osborne, Jr. Charles F
 2. Date of Event Requiring Statement (Month/Day/Year)
05/02/2014		 3. Issuer Name and Ticker or Trading Symbol
SCYNEXIS INC [SCYX]
(Last)
(First)
(Middle)
C/O SCYNEXIS, INC.,, 3501 C TRICENTER BOULEVARD		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chief Financial Officer
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

DURHAM, NC 27713		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 8,950
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy)   (1) 10/21/2014 Common Stock 960 $ 20.4 D  
Stock Option (right to buy)   (1) 04/27/2015 Common Stock 934 $ 20.4 D  
Stock Option (right to buy)   (1) 04/19/2016 Common Stock 490 $ 20.4 D  
Stock Option (right to buy)   (1) 04/25/2017 Common Stock 1,225 $ 20.4 D  
Stock Option (right to buy)   (1) 04/17/2018 Common Stock 808 $ 20.4 D  
Stock Option (right to buy)   (1) 04/22/2019 Common Stock 1,225 $ 25.5 D  
Stock Option (right to buy)   (1) 07/14/2020 Common Stock 1,470 $ 25.91 D  
Stock Option (right to buy)   (1) 04/20/2020 Common Stock 833 $ 30.6 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Osborne, Jr. Charles F
C/O SCYNEXIS, INC.,
3501 C TRICENTER BOULEVARD
DURHAM, NC 27713		       Chief Financial Officer  

Signatures

/s/ Eileen Pruette, by power of attorney 05/02/2014
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The option vests and becomes exercisable with respect to 25% of the total number of underlying shares on each the first and the second anniversary of the vesting commencement date and with respect to the remaining 50% of the underlying shares on the third anniversary of the vesting commencement date.

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