March 27, 2019

Marco Taglietti
Chief Executive Officer
Scynexis, Inc.
1 Evertrust Plaza, 13th Floor
Jersey City, NJ 07302-6548

       Re: Scynexis Inc.
           Registration Statement on Form S-3
           Filed March 22, 2019
           File No. 333-230449

Dear Dr. Taglietti:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Tonya K. Aldave at (202) 551-3601 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of
Healthcare & Insurance
cc:    Brett White, Esq.