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Important  Notice  Regarding  the  Availability  of  Proxy  Materials  for  the  Annual  Meeting  of  Stockholders  of    SCYNEXIS,  INC.    To Be  Held  On:  June  18,  2019  at  9:30  a.m.  The  Hyatt  Regency  Jersey  City  on  the  Hudson,  2  Exchange  Place,  Jersey  City,  NJ    COMPANY  NUMBER  ACCOUNT  NUMBER  CONTROL  NUMBER    This  communication  is  not  a  form  for  voting  and  presents  only  an  overview  of  the  more  complete  proxy  materials  that  are  availableto  you  on  the  Internet.  We  encourage  you  to  access  and  review  all  of  the  important  information  contained  in  the  proxy  materials  before  voting.    If  you  want  to  receive  a  paper  or  e-mail  copy  of  the  proxy  materials  you  must  request  one,  otherwise  you  will  not  receive  a  paper  ore-mail  copy.  There  is  no  charge  to  you  for  requesting  a  copy.  To  facilitate  timely  delivery,  please  make  the  request  as  instructed  below  before  June  4,  2019.    Please  visit  http://www.astproxyportal.com/ast/18891/,  where  the  following  materials  are  available  for  view:   •  Notice  of  Annual  Meeting  of  Stockholders  •  Proxy  Statement  • 2018  Annual  Report  •  Form  of  Electronic  Proxy  Card  TO  OBTAIN  TELEPHONE:  888-Proxy-NA  (888-776-9962)  or  718-921-8562  (for  international  callers)  PROXY  MATERIALS:  E-MAIL:  info@astfinancial.com  WEBSITE:  https://us.astfinancial.com/OnlineProxyVoting/ProxyVoting/RequestMaterials    TO  VOTE:     ONLINE:  To  access  your  online  proxy  card,  please  visit  www.voteproxy.com  and  follow  the  on-screen  instructions  or  scan  the  QR  code  with  your  smartphone.  You  may  enter  your  voting  instructions  at  www.voteproxy.com  up  until  11:59  PM  Eastern  Time  the  day  before  the  cut-off  or  meeting  date.    IN  PERSON:  You  may  vote  your  shares  in  person  by  attending  theAnnual  Meeting.  Directions  to  theAnnual  Meeting  can  be  found  at  the  end  of  the  proxy  statement  or  by  contacting  Investor  Relations  at  investorrelations@scynexis.com.    MAIL:  You  may  request  a  proxy  card  by  following  the  instructions  above.    Proposal  1.To  elect  the  SCYNEXIS  Board  of  Directors’  six  nominees  as  directors  to  serve  until  the  2020  Annual  Meeting  of  Stockholders  and  until  their  successors  are  duly  elected  and  qualified.    NOMINEES:    Armando  Anido  Steven  C.  Gilman,  Ph.D.  Ann  F.  Hanham,  Ph.D.  David  Hastings  Guy  Macdonald  Marco  Taglietti,  M.D.    Proposal  2.Ratification  of  selection  of  Deloitte  &  Touche  LLP  as  SCYNEXIS,  Inc.’s  independent  registered  public  accounting firm  for  the  fiscal  year  ending  December  31,  2019.    Proposal  3.Approval  of  an  amendment  to  SCYNEXIS’s  Amended  and  Restated  Certificate  of  Incorporation  to  increase  the  total  number  of  authorized  shares  of  common  stock  from  125,000,000  to  250,000,000.    THE  BOARD  OF  DIRECTORS  RECOMMENDS  YOU  VOTE  "FOR  ALL  NOMINEES"  IN  PROPOSAL  1,  AND  "FOR"  PROPOSALS  2  AND  3.    The  undersigned  hereby  acknowledges  receipt  of  the  Notice  of  2019Annual  Meeting  of  Shareholders,  the  Proxy  Statement  and  the  2018Annual  Report  to  Shareholders  furnished  herewith.    Please  note  that  you  cannot  use  this  notice  to  vote  by  mail.