Holder Shares Held % O/S Share Change Filing Date
Federated Global Investment Management Corp. 6,868,400 14.66 2,660,000 3/31/18
Caxton Associates LP 1,915,409 4.09 1,915,409 3/31/18
Broadfin Capital, L.L.C. 1,885,904 4.03 1,559,654 3/31/18
The Vanguard Group, Inc. 1,670,293 3.57 742,706 3/31/18
Dafna Capital Management, LLC 1,636,900 3.49 1,130,000 3/31/18
Sanofi SA 1,548,751 3.31 -128,306 12/31/17
CVI Holdings LLC 1,302,830 2.78 1,302,830 3/31/18
Alta Partners 1,286,311 2.75 -- 2/28/17
Deerfield Management Company, L.P. 1,020,000 2.18 1,020,000 3/31/18
Armistice Capital LLC 1,000,000 2.13 1,000,000 3/31/18