Audit Committee Position

David Hastings

Director

Mr. Hastings joined the board in September 2015. He currently serves as the Chief Financial Officer at Arbutus Biopharma Corp. (Nasdaq: ABUS). Prior to joining Arbutus in June 2018, Mr. Hastings served as the Senior Vice President and Chief Financial Officer of Unilife Corporation from February 2015 to June 2017. From October 2003 to October 2014, he served as Executive Vice President and Chief Financial Officer at Incyte Corporation (Nasdaq: INCY). From February 2000 to September 2003, Mr. Hastings served as Vice President, Chief Financial Officer and Treasurer of ArQule, Inc. (Nasdaq: ARQL). Prior to his employment with ArQule and from June 1997 to February 2000, Mr. Hastings was Vice President and Corporate Controller at Genzyme, Inc. (Nasdaq: GENZ), where he was responsible for the management of the finance department. Prior to his employment with Genzyme and from May 1994 to June 1997, Mr. Hastings was the Director of Finance at Sepracor, Inc., where he was primarily responsible for Sepracor's internal and external reporting. He currently serves as a member of the board of directors of VBL Therapeutics (Nasdaq: VBLT) and Entasis Therapeutics Holdings Inc. (Nasdaq: ETTX). Mr. Hastings received his B.A. in Economics at the University of Vermont.

Chair

Steven C. Gilman, Ph.D.

Director

Dr. Gilman joined the board in February 2015. He currently serves on the board of directors of ContraFect Corporation (Nasdaq: CFRX) as Vice Chairman. Prior to his retirement in April 2019, Dr. Gilman served as the Chairman and Chief Executive Officer of ContraFect since May 2015. He also served as the Executive Vice President, Research & Development and Chief Scientific Officer at Cubist Pharmaceuticals until its acquisition by Merck & Co. in January 2015. Prior to joining Cubist, Dr. Gilman served as President and CEO of ActivBiotics from March 2004 to June 2006 and Chairman and CEO from July 2006 to October 2007. Previously, Dr. Gilman worked at Millennium Pharmaceuticals, Inc., from October 2000 to March 2004 where he held a number of senior leadership roles including Vice President and General Manager, Inflammation. Prior to Millennium, he was Group Director at Pfizer Global Research and Development. He has also held scientific, business and academic appointments at Wyeth, Cytogen Corporation, Temple Medical School and Connecticut College. Dr. Gilman currently serves on the board of directors of Akebia Therapeutics, Inc. (Nasdaq: AKBA), Vericel Corporation (Nasdaq: VCEL), Momenta Pharmaceuticals (Nasdaq: MNTA), the Massachusetts Biotechnology Association, the Northeastern University Drug Discovery Advisory Board and the Penn State University Biotechnology Advisory Board. Dr. Gilman received his Ph.D. and M.S. degrees in Microbiology form Pennsylvania State University, his post-doctoral training at Scripps Clinical and Research Foundation and received a B.A. in Microbiology from Miami University of Ohio.

Member

Ann F. Hanham, Ph.D.

Director

Dr. Hanham has served as a member of the board of directors since December 2008. Prior to becoming a Founding Partner and Managing Director of BAR Capital Management in December 2013, she was a General Partner with Burrill & Company, a life sciences venture capital firm, from 2000 to 2013. From 1998 to 2000, Dr. Hanham was a co-founder and Vice President of Clinical & Regulatory Affairs at InterMune, Inc. (Nasdaq: ITMN). From 1995 to 1998, she served as the Senior Director for Oncology Product Development at Otsuka Pharmaceutical, Inc. and from 1991 to 1995 as the Medical Director for Celtrix Pharmaceuticals Inc. From 1988 to 1991, Dr. Hanham worked for Becton Dickinson and Company (Nasdaq: BDX) in both regulatory and clinical affairs for the monoclonal antibody program, and from 1984 to 1988 as a regulatory toxicologist with the Health Protection Branch of Health and Welfare Canada. Dr. Hanham currently serves on the board of HTC Molecular Diagnostics Inc. (Nasdaq: HTGM). Dr. Hanham holds a Ph.D. from the University of British Columbia, an MSc from Simon Fraser University, and a BSc from the University of Toronto. She was also Board Certified in Toxicology in 1986.

Member

Audit Committee Charter

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Compensation Committee Position

Patrick Machado

Director

Mr. Machado joined the board in September 2015. Mr. Machado is a co-founder of Medivation, Inc., a biopharmaceutical company that was acquired by Pfizer, Inc. in 2016. Prior to his retirement in April 2014, Mr. Machado served as Medivation's Chief Financial Officer since its inception in September 2003 and as its Chief Business Officer since December 2009. From 1998 until 2001, Mr. Machado was employed by ProDuct Health, Inc., a privately held medical device company, as Vice President, Chief Financial Officer and General Counsel (1998-2000) and as Senior Vice President and Chief Financial Officer (2000-2001). From 2001 until 2002, Mr. Machado served as a consultant to Cytyc Corporation (Nasdaq: CYTC) to assist with transitional matters related to Cytyc Corporation's acquisition of ProDuct Health, Inc. Mr. Machado currently serves on the board of directors of biopharmaceutical companies Adverum Biotechnologies, Inc. (Nasdaq: ADVM), Chimerix, Inc. (Nasdaq:CMRX), Roivant Sciences Ltd., Therachon AG, Turnstone Biologics, Auransa Inc., and Armaron Bio Pty. Ltd., where he also serves as chair of the board. Mr. Machado received a J.D. from Harvard Law School and a B.A. and B.S. in German and Economics, respectively, from Santa Clara University.

Chair

Guy Macdonald

Chairman of the Board

Mr. Macdonald joined the board in November 2014 and became Chairman in June 2015. He is the President and Chief Executive Officer and a member of the board of directors of Tetraphase Pharmaceuticals, Inc. (Nasdaq: TTPH) since January 2008. From August 2003 until January 2008, Mr. Macdonald served as Executive Vice President of Operations of Idenix Pharmaceuticals, Inc. (Nasdaq: IDIX), a biopharmaceutical company. From 1981 to 2003 he served in various positions at Merck & Co., Inc. (NYSE: MRK), most recently serving as the Vice President for Anti-Infective and Hospital Products. Mr. Macdonald received an Honors Degree in biochemistry from Dundee University in Dundee, Scotland.

Member

Armando Anido

Director

Mr. Anido has served as Chairman and Chief Executive Officer (CEO) of Zynerba Pharmaceuticals since October 2014. Mr. Anido has more than 30 years of executive, operational and commercial leadership experience in the biopharmaceutical industry.  Prior to Zynerba, Mr. Anido served as CEO of two publicly traded companies. Most recently, he was the CEO of NuPathe Inc., which was acquired by Teva Pharmaceuticals in February 2014. At NuPathe, he led the company through FDA approval of its lead product, Zecuity®, the first transdermal patch for migraine, to pre-launch before the company's acquisition by Teva. He also served as President and CEO of Auxilium Pharmaceuticals, a specialty pharmaceutical company acquired by Endo Pharmaceuticals, Inc. in January 2015. Under Mr. Anido's leadership at Auxilium, sales grew from $42 million in 2005 to more than $260 million in 2011. Prior to Auxilium, Mr. Anido served as Executive Vice President, Sales and Marketing, at MedImmune, where Synagis, an anti-viral for RSV, became a blockbuster product, and prior to that, in senior sales and marketing positions at GlaxoWellcome and Lederle Laboratories. At Lederle, he was Vice President, Anti-Infectives, responsible for the commercialization of the anti-bacterials, Suprax and Zosyn. He is currently a member of the Board of Directors of AURIS Medical Holding AG and Life Science PA, and he was a member of the Board of Directors of Adolor Corporation until it was sold to Cubist Pharmaceuticals in December 2011. Mr. Anido earned a BS in Pharmacy and an MBA from West Virginia University.

Member

Compensation Committee Charter

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Nominating and Corporate Governance Committee Position

Ann F. Hanham, Ph.D.

Director

Dr. Hanham has served as a member of the board of directors since December 2008. Prior to becoming a Founding Partner and Managing Director of BAR Capital Management in December 2013, she was a General Partner with Burrill & Company, a life sciences venture capital firm, from 2000 to 2013. From 1998 to 2000, Dr. Hanham was a co-founder and Vice President of Clinical & Regulatory Affairs at InterMune, Inc. (Nasdaq: ITMN). From 1995 to 1998, she served as the Senior Director for Oncology Product Development at Otsuka Pharmaceutical, Inc. and from 1991 to 1995 as the Medical Director for Celtrix Pharmaceuticals Inc. From 1988 to 1991, Dr. Hanham worked for Becton Dickinson and Company (Nasdaq: BDX) in both regulatory and clinical affairs for the monoclonal antibody program, and from 1984 to 1988 as a regulatory toxicologist with the Health Protection Branch of Health and Welfare Canada. Dr. Hanham currently serves on the board of HTC Molecular Diagnostics Inc. (Nasdaq: HTGM). Dr. Hanham holds a Ph.D. from the University of British Columbia, an MSc from Simon Fraser University, and a BSc from the University of Toronto. She was also Board Certified in Toxicology in 1986.

Chair

Steven C. Gilman, Ph.D.

Director

Dr. Gilman joined the board in February 2015. He currently serves on the board of directors of ContraFect Corporation (Nasdaq: CFRX) as Vice Chairman. Prior to his retirement in April 2019, Dr. Gilman served as the Chairman and Chief Executive Officer of ContraFect since May 2015. He also served as the Executive Vice President, Research & Development and Chief Scientific Officer at Cubist Pharmaceuticals until its acquisition by Merck & Co. in January 2015. Prior to joining Cubist, Dr. Gilman served as President and CEO of ActivBiotics from March 2004 to June 2006 and Chairman and CEO from July 2006 to October 2007. Previously, Dr. Gilman worked at Millennium Pharmaceuticals, Inc., from October 2000 to March 2004 where he held a number of senior leadership roles including Vice President and General Manager, Inflammation. Prior to Millennium, he was Group Director at Pfizer Global Research and Development. He has also held scientific, business and academic appointments at Wyeth, Cytogen Corporation, Temple Medical School and Connecticut College. Dr. Gilman currently serves on the board of directors of Akebia Therapeutics, Inc. (Nasdaq: AKBA), Vericel Corporation (Nasdaq: VCEL), Momenta Pharmaceuticals (Nasdaq: MNTA), the Massachusetts Biotechnology Association, the Northeastern University Drug Discovery Advisory Board and the Penn State University Biotechnology Advisory Board. Dr. Gilman received his Ph.D. and M.S. degrees in Microbiology form Pennsylvania State University, his post-doctoral training at Scripps Clinical and Research Foundation and received a B.A. in Microbiology from Miami University of Ohio.

Member

Patrick Machado

Director

Mr. Machado joined the board in September 2015. Mr. Machado is a co-founder of Medivation, Inc., a biopharmaceutical company that was acquired by Pfizer, Inc. in 2016. Prior to his retirement in April 2014, Mr. Machado served as Medivation's Chief Financial Officer since its inception in September 2003 and as its Chief Business Officer since December 2009. From 1998 until 2001, Mr. Machado was employed by ProDuct Health, Inc., a privately held medical device company, as Vice President, Chief Financial Officer and General Counsel (1998-2000) and as Senior Vice President and Chief Financial Officer (2000-2001). From 2001 until 2002, Mr. Machado served as a consultant to Cytyc Corporation (Nasdaq: CYTC) to assist with transitional matters related to Cytyc Corporation's acquisition of ProDuct Health, Inc. Mr. Machado currently serves on the board of directors of biopharmaceutical companies Adverum Biotechnologies, Inc. (Nasdaq: ADVM), Chimerix, Inc. (Nasdaq:CMRX), Roivant Sciences Ltd., Therachon AG, Turnstone Biologics, Auransa Inc., and Armaron Bio Pty. Ltd., where he also serves as chair of the board. Mr. Machado received a J.D. from Harvard Law School and a B.A. and B.S. in German and Economics, respectively, from Santa Clara University.

Member

Nominating and Corporate Governance Committee Charter

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