SCYNEXIS Presents New Data Further Supporting SCY-078 as a Potential Treatment for Aspergillus and Candida Infections at IDWeek 2017
“The data presented at IDWeek demonstrate the broad activity and potential clinical utility of SCY-078 against invasive Candida and Aspergillus infections as well as the significant tissue distribution of oral and IV SCY-078,” said
“The increasing rates of resistance observed in Candida and Aspergillus species to available therapies create an urgent need for novel antifungal agents,” said
SCY-078 Shows Potent Activity Against Invasive Aspergillus (IA)
The first poster, “SCY-078 Demonstrates Significant Antifungal Activity in a Murine Model of Invasive Aspergillosis,” details results of a study designed to evaluate the in vivo antifungal activity of oral SCY-078 in a neutropenic murine model of IA. SCY-078 demonstrated potent activity against wild-type (WT) and azole-resistant strains of A. fumigatus, achieving the primary endpoint of survival at day 14 as well as secondary endpoints of change in fungal kidney burden and serum galactomannan index. These encouraging results support the continued development of oral SCY-078 as a treatment for Aspergillus infections.
SCY-078 Shows Compelling Activity Against WT, Azole-Resistant and Echinocandin-Resistant C. parapsilosis Strains
The second poster, “Assessment of the In Vitro Antifungal Activity of SCY-078 Against a Collection of Candida parapsilosis Clinical Isolates,” details results of a study designed to evaluate the in vitro antifungal activity of SCY-078 against a collection of 206 clinical C. parapsilosis isolates. SCY-078 demonstrated significant activity, as measured by minimum inhibitory concentrations (MIC), against C. parapsilosis isolates, including WT, azole-resistant and echinocandin-resistant strains.
SCY-078 Shows Significant Tissue Penetration Following Oral or
The third poster, “SCY-078 Demonstrates Significant Tissue Penetration in Rats and Mice Following Oral or IV Administration,” details results of several studies designed to evaluate tissue distribution of SCY-078 in rats and mice following oral or IV administration. In both models, SCY-078 demonstrated significant tissue penetration at clinically meaningful levels in various target organs. Specifically, the concentrations observed in lung, vaginal tissue and kidney, among other tissues, exceeded the plasma concentrations several fold. These results reinforce the potential therapeutic benefit of orally and intravenously administered SCY-078 for both treatment and prophylaxis of invasive fungal infections.
All presentations are available on the
SCY-078 is an antifungal agent in clinical development for the treatment of fungal infections caused by Candida and Aspergillus species. SCY-078 is a triterpenoid, semi-synthetic derivative of the natural product enfumafungin – a structurally distinct and novel class of glucan synthase inhibitor. SCY-078 combines the well-established activity of glucan synthase inhibitors with the potential flexibility of having IV and oral formulations. By belonging to a chemical class distinct from other antifungals, SCY-078 has shown in vitro and in vivo activity against multi-drug resistant pathogens, including azole- and echinocandin-resistant strains. The U.S. Food and Drug Administration granted Fast Track, Qualified Infectious Disease Product and Orphan Drug Designations for the formulations of SCY-078 for the indications of invasive candidiasis (including candidemia) and invasive aspergillosis.
Forward Looking Statement
Statements contained in this press release maybe, "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These risks and uncertainties include, but are not limited, to: risks inherent in
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Source: SCYNEXIS, Inc.