SCYNEXIS Data Presentations at ECCMID 2018 Show SCY-078 Potent and Synergistic Antifungal Activity Against Aspergillus and Pneumocystis
"The data presented at ECCMID, together with the recently published study results, contribute to a growing body of evidence supporting SCY-078's potent antifungal activity and showcase its synergy with azole therapy against Aspergillus strains, which are associated with high mortality and increasing rates of resistance to existing therapeutic options," said
Poster Title: "InVitro Activity of SCY-078, a Novel IV/Oral Glucan Synthase Inhibitor, against Aspergillus spp., Alone or in Combination with other Antifungal Therapies"
The poster highlights results of a study designed to evaluate the in vitro activity of SCY-078, alone or in combination with amphotericin B, isavuconazole or voriconazole, against 311 Aspergillus strains. SCY-078 demonstrated potent antifungal activity against these isolates independently and synergistic behavior was observed in combination with amphotericin B, voriconazole and isavuconazole.
Poster Title: "Activity of SCY-078 and comparators against a collection of Aspergillus spp., including cryptic species and Cyp51A mutants"
The poster highlights results from a study designed to evaluate the in vitro activity of SCY-078 against 172 Aspergillus strains, including cryptic species and azole-resistant A. fumigatus isolates (Cyp51A mutants). SCY-078 demonstrated activity against most cryptic species and all azole-resistant A. fumigatus isolates.
Poster Title: "SCY-078 Demonstrates Antifungal Activity Against Pneumocystis in a Prophylactic Murine Model of Pneumocystis Pneumonia"
The poster highlights results from a study designed to evaluate the in vivo activity of oral SCY-078 against Pneumocystis pneumonia, a significant risk for immunocompromised patients. Oral SCY-078 was evaluated at three dose levels (7.5mg/kg, 15mg/kg or 30mg/kg, twice daily), compared to trimethoprim/sulfamethoxazole 50/250mg/kg three times weekly, the current standard of care, and vehicle control. At each dose level, oral SCY-078 demonstrated activity against Pneumocystis pneumonia, as determined by a reduction in organism burden and improved survival, supporting future clinical studies of SCY-078 for prophylaxis.
All presentations are available on the Scientific Publications page of the SCYNEXIS website.
In the study, "SCY-078, a Novel Oral Glucan Synthase Inhibitor, for the Treatment of Invasive Aspergillosis: Evaluation of Antifungal Activity Singly and in Combination," researchers provide a comprehensive evaluation of the in vitro activity of SCY-078 against different Aspergillus species, including azole-resistant isolates. Results illustrated SCY-078's potent antifungal activity against a large panel of isolates at concentrations indicative of a potential clinically-relevant effect. SCY-078 was also evaluated in combination with isavuconazole, voriconazole and amphotericin B in clinical strains of A. fumigatus, including azole-resistant strains. The combination of SCY-078 with each of the three agents generally displayed synergistic activity against the isolates tested.
SCY-078 is an investigational antifungal agent that is a semi-synthetic derivative of the natural product enfumafungin. SCY-078 is the first representative of a novel class of structurally-distinct glucan synthase inhibitors, triterpenoids. This agent combines the well-established activity of glucan synthase inhibitors with the potential flexibility of having IV and oral formulations. SCY-078 is currently in development for the treatment of fungal infections caused primarily by Candida (including C. auris) and Aspergillus species. It has demonstrated broad spectrum of anti-fungal activity, in vitro and in vivo, against multi-drug resistant pathogens, including azole- and echinocandin-resistant strains. The
Forward Looking Statement
Statements contained in this press release regarding expected future events or results, including but not limited to the Company's plans regarding clinical developments, potential LPAD designation and timing of data review for the FURI and CARES trials, are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These risks and uncertainties include, but are not limited, to: risks inherent in SCYNEXIS's ability to successfully develop and obtain FDA approval for SCY-078; the expected costs of studies and when they might begin or be concluded; and SCYNEXIS's reliance on third parties to conduct SCYNEXIS's clinical studies. These and other risks are described more fully in SCYNEXIS's filings with the Securities and Exchange Commission, including without limitation, its most recent Annual Report on Form 10-K under the caption "Risk Factors" and other documents subsequently filed with or furnished to the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. SCYNEXIS undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.
MacDougall Biomedical Communications
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